Dclre1b (基因名), 5' exonuclease Apollo (蛋白名), dcr1b_mouse.
产品名称:
Mouse Dclre1b/ 5' exonuclease Apollo CLIA Kit
货号:
U2633m
商标:
EIAab®
监管等级:
别名:
DNA cross-link repair 1B protein, SNM1 homolog B, Snm1b
检测方法:
CLIA
特异性:
Natural and recombinant mouse 5' exonuclease Apollo
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2, HSPA8 and HSPA14. Interacts with SPAG5 (By similarity). Interacts with TERF2; the interaction is direct.
功能:
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
亚细胞位置:
Chromosome
Telomere
Nucleus
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
数据库链接
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
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