Human DCLRE1B/ 5' exonuclease Apollo CLIA Kit

货号:

U2633h

商标:

EIAab^®

监管等级:

RUO

别名:

DNA cross-link repair 1B protein, SNM1 homolog B, SNMIB, SNM1B

检测方法:

CLIA

特异性:

Natural and recombinant human 5' exonuclease Apollo

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human DCLRE1B CLIA Kit

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通用注释

亚单元:

Interacts with TERF2; the interaction is direct. Interacts with MUS81, MRE11 and FANCD2. Interacts with HSPA2, HSPA8 and HSPA14. Interacts with SPAG5.

功能:

5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.

亚细胞位置:

Chromosome Telomere Nucleus Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.

数据库链接

UniGene:

Hs.591412

SMR:

Q9H816

STRING:

9606.ENSP00000358576

KEGG:

hsa:64858

MIM:

305000

Pfam: