Bad (基因名), Bcl2-associated agonist of cell death (蛋白名), bad_rat.
产品名称:
Rat Bad/ Bcl2-associated agonist of cell death CLIA Kit
细胞死亡Bcl2拮抗剂
货号:
U15040r
商标:
EIAab®
监管等级:
别名:
Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, BAD
检测方法:
CLIA
实验类型:
Sandwich
特异性:
Natural and recombinant rat Bcl2-associated agonist of cell death
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10. The Ser-113/Ser-137 phosphorylated form binds 14-3-3 proteins. Interacts with AKT1 and PIM3 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX (By similarity). Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (PubMed:17998337).
功能:
Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
亚细胞位置:
Mitochondrion outer membrane
Cytoplasm
Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm.
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