Human BAD/ Bcl2-associated agonist of cell death CLIA Kit
细胞死亡Bcl2拮抗剂

货号:

U15040h

商标:

EIAab^®

监管等级:

RUO

别名:

Bcl-2-binding component 6, Bcl-2-like protein 8, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bcl2-L-8, BAD, BBC6, BCL2L8

检测方法:

CLIA

特异性:

Natural and recombinant human Bcl2-associated agonist of cell death

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Human BAD CLIA Kit

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通用注释

亚单元:

Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins (By similarity). Interacts with AKT1 and PIM3. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BAD with BCL2 (By similarity). Interacts with HIF3A (via C-terminus domain); the interaction reduces the binding between BAD and BAX.

功能:

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

亚细胞位置:

Mitochondrion outer membrane Cytoplasm Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.

数据库链接

UniGene:

Hs.370254

SMR:

Q92934

STRING:

9606.ENSP00000309103

KEGG:

hsa:572

MIM: