Rat Bcl2l1/ Bcl-2-like protein 1 CLIA Kit
Bcl2-L-1

货号:

U15265r

商标:

EIAab^®

监管等级:

RUO

别名:

Apoptosis regulator Bcl-X, Bcl2-L-1, Bclx, Blc2l

检测方法:

CLIA

特异性:

Natural and recombinant rat Bcl-2-like protein 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Rat Bcl2l1 CLIA Kit

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通用注释

亚单元:

Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Isoform Bcl-X(L) interacts with SIVA1 isoform 1; the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase. Interacts with VDAC1 (By similarity). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (By similarity). Interacts with BCL2L11 (via BH3).

功能:

Isoform Bcl-X(S) promotes apoptosis.

亚细胞位置:

Isoform Bcl-X(L) Mitochondrion inner membrane Mitochondrion outer membrane Mitochondrion matrix Cytoplasmic vesicle Secretory vesicle Synaptic vesicle membrane Cytoplasm Cytosol Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Nucleus membrane Single-pass membrane protein Cytoplasmic side Localizes to the centrosome when phosphorylated at Ser-49 (By similarity). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner.

数据库链接

UniGene:

Rn.10323

SMR:

P53563

STRING:

10116.ENSRNOP00000043542

KEGG:

rno:24888

Pfam:

PF00452

Uniprot: