BCL2L1 (基因名), Bcl-2-like protein 1 (蛋白名), b2cl1_human.
产品名称:
Human BCL2L1/ Bcl-2-like protein 1 CLIA Kit
Bcl2-L-1
货号:
U15265h
商标:
EIAab®
监管等级:
别名:
Apoptosis regulator Bcl-X, Bcl2-L-1, BCL2L, BCLX
检测方法:
CLIA
特异性:
Natural and recombinant human Bcl-2-like protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with BAD. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2. Isoform Bcl-X(L) interacts with BOP/C22orf29. Interacts with p53/TP53 and BBC3; interaction with BBC3 disrupts the interaction with p53/TP53. Isoform Bcl-X(L) interacts with DNM1L and CLTA; DNM1L and BCL2L1 isoform BCL-X(L) may form a complex in synaptic vesicles that also contains clathrin and MFF. Interacts with ATP5A and ATP5B; the interactions mediate the association of isoform Bcl-X(L) with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase. Interacts with VDAC1 (PubMed:25296756). Isoform Bcl-X(L) interacts (via the loop between motifs BH4 and BH3) with NLRP1 (via LRR repeats), but not with NLRP2, NLRP3, NLRP4, PYCARD, nor MEFV (PubMed:17418785). Interacts with BCL2L11 (via BH3) (PubMed:27013495).
功能:
Isoform Bcl-X(S) promotes apoptosis.
亚细胞位置:
Isoform Bcl-X(L)
Mitochondrion inner membrane
Mitochondrion outer membrane
Mitochondrion matrix
Cytoplasmic vesicle
Secretory vesicle
Synaptic vesicle membrane
Cytoplasm
Cytosol
Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome
Nucleus membrane
Single-pass membrane protein
Cytoplasmic side
After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner (By similarity). Localizes to the centrosome when phosphorylated at Ser-49.
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