Mouse Aph1a/ Gamma-secretase subunit APH-1A CLIA Kit
γ-分泌

货号:

U0406m

商标:

EIAab^®

监管等级:

RUO

别名:

Aph-1alpha, APH-1a

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

0.2-12.5ng/mL

特异性:

Natural and recombinant mouse Gamma-secretase subunit APH-1A

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Neurosciences

规格 & 价格:

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Mouse Aph1a CLIA Kit

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产品说明书

说明书:

MSDS:

在线询价

数据
文献 ( 1 )
序列 / 3D
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通用注释

亚单元:

The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2.

功能:

Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:15634781, PubMed:19369254). Required for normal gamma-secretase assembly (PubMed:15634781, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

亚细胞位置:

Endoplasmic reticulum membrane Multi-pass membrane protein Golgi apparatus Golgi stack membrane Multi-pass membrane protein Predominantly located in the endoplasmic reticulum and in the cis-Golgi.

数据库链接

UniGene:

Mm.306954

SMR:

Q8BVF7

STRING:

10090.ENSMUSP00000058846

KEGG:

mmu:226548

Pfam:

PF06105

Uniprot: