APH1A (基因名), Gamma-secretase subunit APH-1A (蛋白名), aph1a_human.
产品名称:
Human APH1A/ Gamma-secretase subunit APH-1A CLIA Kit
γ-分泌
货号:
U0406h
商标:
EIAab®
监管等级:
别名:
Aph-1alpha, Presenilin-stabilization factor, CGI-78, UNQ579/PRO1141, APH-1a, PSF
检测方法:
CLIA
实验类型:
Sandwich
检测范围:
0.2-12.5ng/mL
特异性:
Natural and recombinant human Gamma-secretase subunit APH-1A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Neurosciences
通用注释
亚单元:
The functional gamma-secretase complex is composed of at least four polypeptides: a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2 (PubMed:12297508, PubMed:12740439, PubMed:19369254, PubMed:25043039, PubMed:26623517, PubMed:26280335).
功能:
Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein) (PubMed:12297508, PubMed:12522139, PubMed:12763021, PubMed:12679784, PubMed:25043039, PubMed:26280335). Required for normal gamma-secretase assembly (PubMed:12522139, PubMed:12471034, PubMed:12763021, PubMed:19369254). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.
亚细胞位置:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Golgi apparatus
Golgi stack membrane
Multi-pass membrane protein
Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
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