YWHAQ (基因名), 14-3-3 protein theta (蛋白名), 1433T_BOVIN.
Homodimer. Interacts with CDK16 (By similarity). Interacts with RGS7 (phosphorylated form). Interacts with SSH1. Interacts with CDKN1B ('Thr-198' phosphorylated form); the interaction translocates CDKN1B to the cytoplasm. Interacts with GAB2. Interacts with the 'Ser-241' phosphorylated form of PDPK1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1.
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
MEKTELIQKA | KLAEQAERYD | DMATCMKAVT | EQGAELSNEE | RNLLSVAYKN |
VVGGRRSAWR | VISSIEQKTD | TSDKKLQLIK | DYREKVESEL | RSICTTVLEL |
LDKYLIANAT | NPESKVFYLK | MKGDYFRYLA | EVACGDDRKQ | TIDNSQGAYQ |
EAFDISKKEM | QPTHPIRLGL | ALNFSVFYYE | ILNNPELACT | LAKTAFDEAI |
AELDTLNEDS | YKDSTLIMQL | LRDNLTLWTS | DSAGEECDAA | EGAEN
"A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord."
"An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes."
"Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils."
"ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding."
"Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study."
"SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner."
"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
"Structural basis for protein-protein interactions in the 14-3-3 protein family."
"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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