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KIRREL1 (基因名), Kin of IRRE-like protein 1 (蛋白名), kirr1_human.
产品名称:

Human KIRREL1/ Kin of IRRE-like protein 1 Recombinant Protein
肾病样蛋白1

货号:

R2838h

商标:
EIAab®
监管等级:
别名:

Kin of irregular chiasm-like protein 1, Nephrin-like protein 1, KIRREL, NEPH1

序列号:
Q96J84
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human KIRREL1 Protein
规格 & 价格: cart
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Human KIRREL1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q23.1 by HGNC 1q23.1 by Entrez Gene 1q23.1 by Ensembl
KIRREL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL1 glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2 (By similarity).


功能:
Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity).


亚细胞位置:
Cell membrane Single-pass type I membrane protein Predominantly located at podocyte slit diaphragm.


该产品尚未在任何出版物中被引用。

[1].
"Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy."

[2].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[3].
"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"NEPH1 defines a novel family of podocin interacting proteins."

[6].
"Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1."

[7].
"Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN."

[8].
"The MYO6 interactome reveals adaptor complexes coordinating early endosome and cytoskeletal dynamics."

[9].
"Architecture of the human interactome defines protein communities and disease networks."

[10].
"The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery."
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