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KCNJ10 (基因名), ATP-sensitive inward rectifier potassium channel 10 (蛋白名), irk10_human.
产品名称:

Human KCNJ10/ ATP-sensitive inward rectifier potassium channel 10 Recombinant Protein
ATP敏感的内向整流钾通道10

货号:

R5460h

商标:
EIAab®
监管等级:
别名:

ATP-dependent inwardly rectifying potassium channel Kir4.1, Inward rectifier K(+) channel Kir1.2, Potassium channel, inwardly rectifying subfamily J member 10

序列号:
P78508
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Signal Transduction
Human KCNJ10 Protein
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Human KCNJ10 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1q23.2 by HGNC 1q23.2 by Entrez Gene 1q23.2 by Ensembl
KCNJ10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Seems to form heterodimer with Kir5.1/KCNJ16. Interacts with INADL.


功能:
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.


亚细胞位置:
Membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy."

[2].
"Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)."

[3].
"Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome."

[4].
"No association between the KCNH1, KCNJ10 and KCNN3 genes and schizophrenia in the Han Chinese population."

[5].
"Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct."

[6].
"Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10."

[7].
"Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations."

[8].
"Analysis of gene polymorphisms associated with K ion circulation in the inner ear of patients susceptible and resistant to noise-induced hearing loss."

[9].
"Association analysis of chromosome 1 migraine candidate genes."

[10].
"The DNA sequence and biological annotation of human chromosome 1."
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