Dynll1 (GeneName), Dynein light chain 1, cytoplasmic (ProteinName), dyl1_mouse.
Mouse Dynll1/ Dynein light chain 1, cytoplasmic Recombinant Protein
8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN,Dlc1,Dncl1,Dnclc1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
R&D Technical Data
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Homodimer. Monomer; the monomeric form is incapable of binding to target proteins. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with TXNDC17. Interacts with WWC1 and ESR1. The interaction with WWC1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin. Interacts with BCL2; the interaction is greatly enhanced in the nucleus and in mitochondria upon induction of apoptosis. Interacts with PAK1; the interaction requires dimeric DYNLL1. Interacts with MYZAP. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGO2. Interacts with ATMIN; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. Interacts with NEK9 (not phosphorylated at 'Ser-944') (By similarity). Interacts with BCL2L11 (PubMed:21478148). Interacts with BICD2 (PubMed:22956769).
Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.
Cytoplasm Cytoskeleton Nucleus Mitochondrion
This product has not yet been referenced specifically in any publications.
"Serine 88 phosphorylation of the 8-kDa dynein light chain 1 is a molecular switch for its dimerization status and functions."
"Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes."
"The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex."
"Structure of the PIN/LC8 dimer with a bound peptide."
"Cytoplasmic dynein (ddlc1) mutations cause morphogenetic defects and apoptotic cell death in Drosophila melanogaster."
"Structural analysis of the regulation of the DYNLL/LC8 binding to Nek9 by phosphorylation."
"ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Structural basis for the interaction between dynein light chain 1 and the glutamate channel homolog GRINL1A."
"Biochemical and structural characterization of the Pak1-LC8 interaction."
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