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ATOH1 (基因名), Protein atonal homolog 1 (蛋白名), atoh1_human.
产品名称:

Human ATOH1/ Protein atonal homolog 1 Recombinant Protein
无调性同源蛋白1

货号:

R0255h

商标:
EIAab®
监管等级:
别名:

Class A basic helix-loop-helix protein 14, Helix-loop-helix protein hATH-1, bHLHa14, hATH1, ATH1, BHLHA14

序列号:
Q92858
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Development Biology
Human ATOH1 Protein
规格 & 价格: cart
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Human ATOH1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 4q22.2 by HGNC 4q22.2 by Entrez Gene 4q22.2 by Ensembl
ATOH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Efficient DNA binding requires dimerization with another bHLH protein.


功能:
Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis."

[2].
"Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer."

[3].
"Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors."

[4].
"The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1."

[5].
"A role for Hath1, a bHLH transcription factor, in colon adenocarcinoma."

[6].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[7].
"Molecular characterization and mapping of ATOH7, a human atonal homolog with a predicted role in retinal ganglion cell development."

[8].
"Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals."

[9].
"Prognostic relevance of high atonal homolog-1 expression in Merkel cell carcinoma."

[10].
"Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth."
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