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Msl1 (基因名), Male-specific lethal 1 homolog (蛋白名), MSL1_MOUSE.
产品名称:

Mouse Msl1/ Male-specific lethal 1 homolog Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Hampin, Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1, MSL1-like 1, MSL-1, Msl1l1

序列号:
Q6PDM1
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Msl1 Protein
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Mouse Msl1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Directly interacts with MSL2 via its coiled coil domain (By similarity). Directly interacts with NUPR1 (By similarity). Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (By similarity). Forms a MSL heterotetrameric core with MSL2 (By similarity). Interacts with KAT8 and MSL3; both interactions are direct.


功能:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-17' which is implicated in the formation of higher-order chromatin. structure (By similarity). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。
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