MSL1 (基因名), Male-specific lethal 1 homolog (蛋白名), MSL1_HUMAN.
Human MSL1/ Male-specific lethal 1 homolog Recombinant Protein
Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1, MSL1-like 1, MSL-1, MSL1L1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
MTMRSAVFKA | AAAPAGGNPE | QRLDYERAAA | LGGPEDEPGA | AEAHFLPRHR |
KLKEPGPPLA | SSQGGSPAPS | PAGCGGKGRG | LLLPAGAAPG | QQEESWGGSV |
PLPCPPPATK | QAGIGGEPAA | AGAGCSPRPK | YQAVLPIQTG | SLVAAAKEPT |
PWAGDKGGAA | SPAATASDPA | GPPPLPLPGP | PPLAPTATAG | TLAASEGRWK |
SMRKSPLGGG | GGSGASSQAA | CLKQILLLQL | DLIEQQQQQL | QAKEKEIEEL |
KSERDTLLAR | IERMERRMQL | VKKDNEKERH | KLFQGYETEE | REETELSEKI |
KLECQPELSE | TSQTLPPKPF | SCGRSGKGHK | RKSPFGSTER | KTPVKKLAPE |
FSKVKTKTPK | HSPIKEEPCG | SLSETVCKRE | LRSQETPEKP | RSSVDTPPRL |
STPQKGPSTH | PKEKAFSSEI | EDLPYLSTTE | MYLCRWHQPP | PSPLPLRESS |
PKKEETVARC | LMPSSVAGET | SVLAVPSWRD | HSVEPLRDPN | PSDLLENLDD |
SVFSKRHAKL | ELDEKRRKRW | DIQRIREQRI | LQRLQLRMYK | KKGIQESEPE |
VTSFFPEPDD | VESLMITPFL | PVVAFGRPLP | KLTPQNFELP | WLDERSRCRL |
EIQKKQTPHR | TCRK
"A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."
"Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila."
"Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."
"The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."
"p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."
"Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila."
"Architecture of the human interactome defines protein communities and disease networks."
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."
"A High-Density Map for Navigating the Human Polycomb Complexome."
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."
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