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MSL1 (基因名), Male-specific lethal 1 homolog (蛋白名), MSL1_HUMAN.
产品名称:

Human MSL1/ Male-specific lethal 1 homolog Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Male-specific lethal 1-like 1, Male-specific lethal-1 homolog 1, MSL1-like 1, MSL-1, MSL1L1

序列号:
Q68DK7
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MSL1 Protein
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Human MSL1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 17q21.1 by HGNC 17q21.1 by Entrez Gene 17q21.1 by Ensembl
MSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3. Forms a MSL heterotetrameric core with MSL2. Interacts with KAT8 and MSL3; both interactions are direct. Directly interacts with NUPR1. Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity.


功能:
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16."

[2].
"Msl1-mediated dimerization of the dosage compensation complex is essential for male X-chromosome regulation in Drosophila."

[3].
"Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1."

[4].
"The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K79 methylation."

[5].
"p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."

[6].
"Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila."

[7].
"Architecture of the human interactome defines protein communities and disease networks."

[8].
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."

[9].
"A High-Density Map for Navigating the Human Polycomb Complexome."

[10].
"Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes."
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