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MSH3 (基因名), DNA mismatch repair protein Msh3 (蛋白名), MSH3_HUMAN.
产品名称:

Human MSH3/ DNA mismatch repair protein Msh3 Recombinant Protein

货号:

R2359h

商标:
EIAab®
监管等级:
别名:

Divergent upstream protein, Mismatch repair protein 1, DUP, MRP1, hMSH3, DUC1, DUG

序列号:
P20585
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MSH3 Protein
规格 & 价格: cart
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Human MSH3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 5q14.1 by HGNC 5q14.1 by Entrez Gene 5q14.1 by Ensembl
MSH3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1.


功能:
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Common variants in mismatch repair genes and risk of invasive ovarian cancer."

[2].
"Association between single nucleotide polymorphisms in the hMSH3 gene and sporadic colon cancer with microsatellite instability."

[3].
"Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair."

[4].
"hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6."

[5].
"Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis."
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