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MSH2 (基因名), DNA mismatch repair protein Msh2 (蛋白名), MSH2_HUMAN.
产品名称:

Human MSH2/ DNA mismatch repair protein Msh2 Recombinant Protein
DNA错配修复蛋白MSH2

货号:

R8706h

商标:
EIAab®
监管等级:
别名:

MutS protein homolog 2, hMSH2

序列号:
P43246
来源:
E.coli
种属:
Human
标签:
His
序列:
321-574aa
预估分子量:
27.94 kDa (monomer)
纯度:
Greater than 95% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
  • Human MSH2 Protein
  • Human MSH2 Protein
  • Human MSH2 Protein
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Human MSH2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
Human MSH2 Protein
The PCR product of human MSH2 gene was determined by 1% Agarose stained with EB.
Human MSH2 Protein
Recombinant human MSH2 protein was determined by 12% SDS-PAGE stained with Coomassie Blue under reducing conditions.
基因位点
Cytogenetic band: 2p21-p16.3 by HGNC 2p21-p16.3 by Entrez Gene 2p21-p16.3 by Ensembl
MSH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2-MSH3 (MutS beta). Both heterodimer form a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR. Interacts with SLX4/BTBD12; this interaction is direct and links MutS beta to SLX4, a subunit of different structure-specific endonucleases. Interacts with SMARCAD1.


功能:
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians."

[2].
"Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management."

[3].
"Mechanisms of pathogenicity in human MSH2 missense mutants."

[4].
"Classification of ambiguous mutations in DNA mismatch repair genes identified in a population-based study of colorectal cancer."

[5].
"Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)."
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