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OIP5 (基因名), Protein Mis18-beta (蛋白名), MS18B_HUMAN.
产品名称:

Human OIP5/ Protein Mis18-beta Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Cancer/testis antigen 86, Opa-interacting protein 5, CT86, OIP-5, MIS18B

序列号:
O43482
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human OIP5 Protein
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Human OIP5 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 15q15.1 by HGNC 15q15.1 by Entrez Gene 15q15.1 by Ensembl
OIP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer, and heterodimer with MIS18A (PubMed:17199038, PubMed:26921242). Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038). Binds outer membrane protein OpaP from Neisseria gonorrhoeae (in vitro) (PubMed:9466265).


功能:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.


亚细胞位置:
Nucleus Chromosome Chromosome Centromere Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.


该产品尚未在任何出版物中被引用。

[1].
"Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1."

[2].
"Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth."

[3].
"Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization."

[4].
"OIP5 is a highly expressed potential therapeutic target for colorectal and gastric cancers."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"Long non-coding RNA OIP5-AS1 functions as an oncogene in lung adenocarcinoma through targeting miR-448/Bcl-2."

[7].
"LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells."

[8].
"Loss of the Opa interacting protein 5 inhibits breast cancer proliferation through miR-139-5p/NOTCH1 pathway."

[9].
"CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading."

[10].
"OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways."
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