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MRVI1 (基因名), Protein MRVI1 (蛋白名), MRVI1_HUMAN.
产品名称:

Human MRVI1/ Protein MRVI1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Inositol 1, 4, 5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1, IRAG, JAW1L

序列号:
Q9Y6F6
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRVI1 Protein
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Human MRVI1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 11p15.4 by HGNC 11p15.4 by Entrez Gene 11p15.4 by Ensembl
MRVI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.


功能:
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.


亚细胞位置:
Cytoplasm Perinuclear region Sarcoplasmic reticulum Membrane Single-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle."

[2].
"Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1."

[3].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[4].
"Inherited genetic variant predisposes to aggressive but not indolent prostate cancer."

[5].
"Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists."

[6].
"IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation."

[7].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[8].
"Association of phospholamban with a cGMP kinase signaling complex."

[9].
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."

[10].
"Genome-wide meta-analysis identifies new susceptibility loci for migraine."
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