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MARCKSL1 (基因名), MARCKS-related protein (蛋白名), MRP_HUMAN.
产品名称:

Human MARCKSL1/ MARCKS-related protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MLP, MRP

序列号:
P49006
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cardiovascular
Human MARCKSL1 Protein
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Human MARCKSL1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 1p35.1 by HGNC 1p35.1 by Entrez Gene 1p35.1 by Ensembl
MARCKSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.


功能:
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.


亚细胞位置:
Cytoplasm Cell membrane Membrane Lipid-anchor Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects."

[2].
"c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells."

[3].
"Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells."

[4].
"A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis."

[5].
"Investigation into the mechanism regulating MRP localization."

[6].
"The regulation of MacMARCKS expression by integrin beta3."

[7].
"The DNA sequence and biological annotation of human chromosome 1."

[8].
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading."
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