MARCKSL1 (基因名), MARCKS-related protein (蛋白名), MRP_HUMAN.
Human MARCKSL1/ MARCKS-related protein Recombinant Protein
MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MLP, MRP
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status.
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Cytoplasm Cell membrane Membrane Lipid-anchor Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin (By similarity). In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes (By similarity).
MGSQSSKAPR | GDVTAEEAAG | ASPAKANGQE | NGHVKSNGDL | SPKGEGESPP |
VNGTDEAAGA | TGDAIEPAPP | SQGAEAKGEV | PPKETPKKKK | KFSFKKPFKL |
SGLSFKRNRK | EGGGDSSASS | PTEEEQEQGE | IGACSDEGTA | QEGKAAATPE |
SQEPQAKGAE | ASAASEEEAG | PQATEPSTPS | GPESGPTPAS | AEQNE
"Promoter sequence, expression, and fine chromosomal mapping of the human gene (MLP) encoding the MARCKS-like protein: identification of neighboring and linked polymorphic loci for MLP and MACS and use in the evaluation of human neural tube defects."
"c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cells."
"Suppression of the lipopolysaccharide-induced expression of MARCKS-related protein (MRP) affects transmigration in activated RAW264.7 cells."
"A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis."
"Investigation into the mechanism regulating MRP localization."
"The regulation of MacMARCKS expression by integrin beta3."
"The DNA sequence and biological annotation of human chromosome 1."
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading."
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