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MRNIP (基因名), MRN complex-interacting protein (蛋白名), MRNIP_HUMAN.
产品名称:

Human MRNIP/ MRN complex-interacting protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MRN-interacting protein, C5orf45

序列号:
Q6NTE8
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRNIP Protein
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Human MRNIP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


基因位点
Cytogenetic band: 5q35.3 by HGNC 5q35.3 by Entrez Gene 5q35.3 by Ensembl
MRNIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Associates with the MRE11-RAD50-NBN (MRN) damage-sensing complex; this association is constitutive (PubMed:27568553). Interacts with MRE11 (PubMed:27568553). Interacts with NBN (PubMed:27568553). Interacts with RAD50 (PubMed:27568553).


功能:
Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).


亚细胞位置:
Nucleus Nucleus Nucleoplasm Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553).


该产品尚未在任何出版物中被引用。

[1].
"MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response."

[2].
"Genome-scale RNAi screen for host factors required for HIV replication."

[3].
"hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes."

[4].
"The full-ORF clone resource of the German cDNA Consortium."

[5].
"The LIFEdb database in 2006."

[6].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[7].
"Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation."

[8].
"From ORFeome to biology: a functional genomics pipeline."

[9].
"The DNA sequence and comparative analysis of human chromosome 5."

[10].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
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