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MRGPRX1 (基因名), Mas-related G-protein coupled receptor member X1 (蛋白名), MRGX1_HUMAN.
产品名称:

Human MRGPRX1/ Mas-related G-protein coupled receptor member X1 Recombinant Protein

货号:

R14370h

商标:
EIAab®
监管等级:
别名:

Sensory neuron-specific G-protein coupled receptor 3/4, MRGX1, SNSR3, SNSR4

序列号:
Q96LB2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRGPRX1 Protein
规格 & 价格: cart
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Human MRGPRX1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 11p15.1 by HGNC 11p15.1 by Entrez Gene 11p15.1 by Ensembl
MRGPRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.


亚细胞位置:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus."

[2].
"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons."

[3].
"Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs."

[6].
"Identification of G protein-coupled receptor genes from the human genome sequence."

[7].
"Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain."

[8].
"Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation."

[9].
"Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes."

[10].
"Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways."
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