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MRGBP (基因名), MRG/MORF4L-binding protein (蛋白名), MRGBP_HUMAN.
产品名称:

Human MRGBP/ MRG/MORF4L-binding protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MRG-binding protein, Up-regulated in colon cancer 4, Urcc4, C20orf20

序列号:
Q9NV56
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRGBP Protein
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Human MRGBP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 20q13.33 by HGNC 20q13.33 by Entrez Gene 20q13.33 by Ensembl
MRGBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.


功能:
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."

[2].
"Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain."

[3].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[4].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[5].
"The DNA sequence and comparative analysis of human chromosome 20."

[6].
"Architecture of the human interactome defines protein communities and disease networks."

[7].
"MRGBP as a potential biomarker for the malignancy of pancreatic ductal adenocarcinoma."

[8].
"Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis."

[9].
"Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation."

[10].
"The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation."
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