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Mre11 (基因名), Double-strand break repair protein MRE11 (蛋白名), MRE11_MOUSE.
产品名称:

Mouse Mre11/ Double-strand break repair protein MRE11 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, Meiotic recombination 11 homolog A, MmMRE11A, MRE11 homolog 1, MRE11 homolog A, Mre11a

序列号:
Q61216
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Mre11 Protein
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Mouse Mre11 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Component of the MRN complex composed of two heterodimers RAD50/MRE11 associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11 and NBN. Found in a complex with TERF2. Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo. Interacts with ATF2. Interacts with EXD2. Interacts with MRNIP.


功能:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.


亚细胞位置:
Nucleus Chromosome Telomere Localizes to discrete nuclear foci after treatment with genotoxic agents.


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