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MRE11 (基因名), Double-strand break repair protein MRE11 (蛋白名), MRE11_HUMAN.
产品名称:

Human MRE11/ Double-strand break repair protein MRE11 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog 1, MRE11 homolog A, HNGS1, MRE11A

序列号:
P49959
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRE11 Protein
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Human MRE11 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 11q21 by HGNC 11q21 by Entrez Gene 11q21 by Ensembl
MRE11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
(Microbial infection) Interacts with herpes simplex virus 1 protein UL12 (PubMed:20943970).


功能:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).


亚细胞位置:
Nucleus Chromosome Telomere Localizes to discrete nuclear foci after treatment with genotoxic agents.


该产品尚未在任何出版物中被引用。

[1].
"Isolation and characterization of the human MRE11 homologue."

[2].
"Alterations of the double-strand break repair gene MRE11 in cancer."

[3].
"Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres."

[4].
"The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks."

[5].
"Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95."

[6].
"SAMHD1 acts at stalled replication forks to prevent interferon induction."

[7].
"SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination."

[8].
"MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response."

[9].
"EXD2 promotes homologous recombination by facilitating DNA end resection."

[10].
"MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex."
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