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CDC42BPB (基因名), Serine/threonine-protein kinase MRCK beta (蛋白名), MRCKB_HUMAN.
产品名称:

Human CDC42BPB/ Serine/threonine-protein kinase MRCK beta Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

CDC42-binding protein kinase beta, DMPK-like beta, Myotonic dystrophy kinase-related CDC42-binding kinase beta, CDC42BP-beta, MRCK beta, KIAA1124

序列号:
Q9Y5S2
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human CDC42BPB Protein
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Human CDC42BPB Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 14q32.32 by HGNC 14q32.32 by Entrez Gene 14q32.32 by Ensembl
CDC42BPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer and homotetramer via the coiled coil regions (PubMed:21949762). Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393). Interacts with CPNE4 (via VWFA domain).


功能:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A.


亚细胞位置:
Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating cells. Localization at the leading edge of migrating cells requires interaction with catalytically active CDC42.


该产品尚未在任何出版物中被引用。

[1].
"Cloning and chromosomal localization of human Cdc42-binding protein kinase beta."

[2].
"CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling."

[3].
"Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion."

[4].
"Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility."

[5].
"Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration."
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