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CDC42BPA (基因名), Serine/threonine-protein kinase MRCK alpha (蛋白名), MRCKA_HUMAN.
产品名称:

Human CDC42BPA/ Serine/threonine-protein kinase MRCK alpha Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

CDC42-binding protein kinase alpha, DMPK-like alpha, Myotonic dystrophy kinase-related CDC42-binding kinase alpha, MRCK alpha, KIAA0451

序列号:
Q5VT25
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human CDC42BPA Protein
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Human CDC42BPA Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 1q42.13 by HGNC 1q42.13 by Entrez Gene 1q42.13 by Ensembl
CDC42BPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation.


功能:
Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.


亚细胞位置:
Cytoplasm Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity).


该产品尚未在任何出版物中被引用。

[1].
"Human MRCKalpha is regulated by cellular iron levels and interferes with transferrin iron uptake."

[2].
"A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."

[3].
"Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion."

[4].
"Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity."

[5].
"Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha."
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