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首页  >  重组蛋白  >  Human MRC2 Recombinant Protein
MRC2 (基因名), C-type mannose receptor 2 (蛋白名), MRC2_HUMAN.
产品名称:

Human MRC2/ C-type mannose receptor 2 Recombinant Protein
C-型甘露糖受体2

货号:

R2105h

商标:
EIAab®
监管等级:
别名:

C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, CD280, CLEC13E, ENDO180, KIAA0709, UPARAP

序列号:
Q9UBG0
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human MRC2 Protein
规格 & 价格: cart
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Human MRC2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 17q23 by HGNC 17q23 by Entrez Gene 17q23 by Ensembl
MRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.


功能:
May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).


亚细胞位置:
Membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor."

[2].
"The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family."

[3].
"Characterization of sugar binding by the mannose receptor family member, Endo180."

[4].
"A urokinase receptor-associated protein with specific collagen binding properties."

[5].
"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

[6].
"Characterization of a novel member of the macrophage mannose receptor type C lectin family."

[7].
"A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion."

[8].
"Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants."

[9].
"Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180."

[10].
"Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer."
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