首页 > 重组蛋白 > Human MRC2 Recombinant Protein

MRC2 (基因名), C-type mannose receptor 2 (蛋白名), MRC2_HUMAN.

产品名称:

Human MRC2/ C-type mannose receptor 2 Recombinant Protein
C-型甘露糖受体2

货号:

R2105h

商标:

EIAab^®

监管等级:

RUO

别名:

C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type plasminogen activator receptor-associated protein, UPAR-associated protein, CD280, CLEC13E, ENDO180, KIAA0709, UPARAP

序列号:

Q9UBG0

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

Immunology

规格 & 价格:

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Human MRC2 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 17q23 by HGNC 17q23 by Entrez Gene 17q23 by Ensembl

MRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with C-terminal region of type I collagen/COL1A1 (By similarity). Interacts directly with PLAUR/UPAR and PLAU/pro-UPA to form a tri-molecular complex. Interacts with collagen V.

功能:

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

亚细胞位置:

Membrane Single-pass type I membrane protein

数据库链接

UniGene:

Hs.7835

SMR:

Q9UBG0

STRING:

9606.ENSP00000307513

KEGG:

hsa:9902

MIM:

612264

Pfam:

PF00040

Uniprot:

Q9UBG0

相关产品

序列长度:

1479

序列:

仅供参考，详细请咨询（services@eiaab.com）

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1479:

RYSRSSSSPT | EATEKNILVS | DMEMNEQQE

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"Identification and characterization of the endocytic transmembrane glycoprotein Endo180 as a novel collagen receptor."

(PMID: 12972549)

[2].

"The C-type lectin receptor Endo180 displays internalization and recycling properties distinct from other members of the mannose receptor family."

(PMID: 12068012)

[3].

"Characterization of sugar binding by the mannose receptor family member, Endo180."

(PMID: 12399458)

[4].

"A urokinase receptor-associated protein with specific collagen binding properties."

(PMID: 10636902)

[5].

"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."

(PMID: 9734811)

[6].

"Characterization of a novel member of the macrophage mannose receptor type C lectin family."

(PMID: 8702911)

[7].

"A role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion."

(PMID: 20339555)

[8].

"Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants."

(PMID: 19584075)

[9].

"Membrane type-1 matrix metalloproteinase activity is regulated by the endocytic collagen receptor Endo180."

(PMID: 19861500)

[10].

"Increased expression of the collagen internalization receptor uPARAP/Endo180 in the stroma of head and neck cancer."

(PMID: 17189524)

[1].

人C-型甘露糖受体2(MRC2)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人C-型甘露糖受体2(MRC2)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人C-型甘露糖受体2(MRC2)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人C-型甘露糖受体2(MRC2)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人C-型甘露糖受体2(MRC2)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人C-型甘露糖受体2(MRC2)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人C-型甘露糖受体2(MRC2)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人C-型甘露糖受体2(MRC2)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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