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MRAP (基因名), Melanocortin-2 receptor accessory protein (蛋白名), MRAP_HUMAN.
产品名称:

Human MRAP/ Melanocortin-2 receptor accessory protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

B27, Fat cell-specific low molecular weight protein, Fat tissue-specific low MW protein, C21orf61, FALP

序列号:
Q8TCY5
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRAP Protein
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Human MRAP Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 21q22.11 by HGNC 21q22.11 by Entrez Gene 21q22.11 by Ensembl
MRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.


功能:
Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.


亚细胞位置:
Cell membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (PubMed:20371771). Upon insulin stimulation, it is redistributed into spotty structures throughout the cytoplasm.


该产品尚未在任何出版物中被引用。

[1].
"Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2."

[2].
"Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2."

[3].
"Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency."

[4].
"Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."

[5].
"Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis."

[6].
"Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking."

[7].
"Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling."

[8].
"MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."

[9].
"Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells."

[10].
"Clinical and biological phenotype of a patient with familial glucocorticoid deficiency type 2 caused by a mutation of melanocortin 2 receptor accessory protein."
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