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MRAP2 (基因名), Melanocortin-2 receptor accessory protein 2 (蛋白名), MRAP2_HUMAN.
产品名称:

Human MRAP2/ Melanocortin-2 receptor accessory protein 2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MC2R accessory protein 2, C6orf117

序列号:
Q96G30
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MRAP2 Protein
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Human MRAP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 6q14.2 by HGNC 6q14.2 by Entrez Gene 6q14.2 by Ensembl
MRAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.


功能:
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.


亚细胞位置:
Cell membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context.


该产品尚未在任何出版物中被引用。

[1].
"Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity."

[2].
"Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."

[3].
"MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[6].
"The DNA sequence and analysis of human chromosome 6."

[7].
"Architecture of the human interactome defines protein communities and disease networks."

[8].
"Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling."

[9].
"Copy number variation (CNV) analysis and mutation analysis of the 6q14.1-6q16.3 genes SIM1 and MRAP2 in Prader Willi like patients."

[10].
"Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene."
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