MRAP2 (基因名), Melanocortin-2 receptor accessory protein 2 (蛋白名), MRAP2_HUMAN.
Human MRAP2/ Melanocortin-2 receptor accessory protein 2 Recombinant Protein
MC2R accessory protein 2, C6orf117
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.
Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (By similarity). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Cell membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context.
MSAQRLISNR | TSQQSASNSD | YTWEYEYYEI | GPVSFEGLKA | HKYSIVIGFW |
VGLAVFVIFM | FFVLTLLTKT | GAPHQDNAES | SEKRFRMNSF | VSDFGRPLEP |
DKVFSRQGNE | ESRSLFHCYI | NEVERLDRAK | ACHQTTALDS | DVQLQEAIRS |
SGQPEEELNR | LMKFDIPNFV | NTDQNYFGED | DLLISEPPIV | LETKPLSQTS |
"Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity."
"Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2."
"MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"The DNA sequence and analysis of human chromosome 6."
"Architecture of the human interactome defines protein communities and disease networks."
"Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling."
"Copy number variation (CNV) analysis and mutation analysis of the 6q14.1-6q16.3 genes SIM1 and MRAP2 in Prader Willi like patients."
"Decreased melanocortin-4 receptor function conferred by an infrequent variant at the human melanocortin receptor accessory protein 2 gene."
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