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M6PR (基因名), Cation-dependent mannose-6-phosphate receptor (蛋白名), MPRD_HUMAN.
产品名称:

Human M6PR/ Cation-dependent mannose-6-phosphate receptor Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

46 kDa mannose 6-phosphate receptor, MPR 46, CD Man-6-P receptor, MPR46, MPRD

序列号:
P20645
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Immunology
Human M6PR Protein
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Human M6PR Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 12p13.31 by HGNC 12p13.31 by Entrez Gene 12p13.31 by Ensembl
M6PR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer. Binds GGA1, GGA2 and GGA3.


功能:
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.


亚细胞位置:
Lysosome membrane Single-pass type I membrane protein


该产品尚未在任何出版物中被引用。

[1].
"Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease."

[2].
"Sorting of mannose 6-phosphate receptors mediated by the GGAs."

[3].
"Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene."

[4].
"Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor."

[5].
"Carbohydrate recognition by the mannose-6-phosphate receptors."

[6].
"High-density association study and nomination of susceptibility genes for hypertension in the Japanese National Project."

[7].
"Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes."

[8].
"Strategies for carbohydrate recognition by the mannose 6-phosphate receptors."

[9].
"SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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