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MPP2 (基因名), MAGUK p55 subfamily member 2 (蛋白名), MPP2_HUMAN.
产品名称:

Human MPP2/ MAGUK p55 subfamily member 2 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Discs large homolog 2, Protein MPP2, DLG2

序列号:
Q14168
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MPP2 Protein
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Human MPP2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 17q21.31 by HGNC 17q21.31 by Entrez Gene 17q21.31 by Ensembl
MPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Can homomultimerise. Interacts with CACNG2. Interacts (via the SH3-Guanylate kinase-like sub-module) with DLG4/PSD95 and DLGAP1/GKAP. Interacts (via the PDZ domain) with CADM1 (via C-terminus) (By similarity). Interacts with KCNN2/SK2 (via N-terminal domain) (By similarity). Interacts with SRC (PubMed:19665017).


功能:
Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2-containing channel function and long-term potentiation expression (By similarity). Seems to negatively regulate SRC function in epithelial cells (PubMed:19665017).


亚细胞位置:
Cytoplasm Cytoskeleton Membrane Cell projection Dendrite Cell projection Dendritic spine membrane Prominently expressed in the post-synaptic densities of dendritic spines, is also detected in dendritic shafts.


该产品尚未在任何出版物中被引用。

[1].
"A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A."

[2].
"The PDZ protein MPP2 interacts with c-Src in epithelial cells."

[3].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[4].
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."

[5].
"Architecture of the human interactome defines protein communities and disease networks."

[6].
"The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors."

[7].
"The BioPlex Network: A Systematic Exploration of the Human Interactome."

[8].
"Heritability and genetic association analysis of cognition in the?Diabetes Heart Study."

[9].
"A proteome-scale map of the human interactome network."

[10].
"Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1."
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