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Cdc25a (基因名), M-phase inducer phosphatase 1 (蛋白名), MPIP1_RAT.
产品名称:

Rat Cdc25a/ M-phase inducer phosphatase 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Dual specificity phosphatase Cdc25A

序列号:
P48965
来源:
E.coli
种属:
Rat
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Rat Cdc25a Protein
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Rat Cdc25a Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages (By similarity). Interacts with PIM1. Interacts with HSP90AB1; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression.


功能:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (By similarity). Phosphorylation by PIM1 leads to an increase in phosphatase activity.


亚细胞位置:
N/A


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