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CDC25A (基因名), M-phase inducer phosphatase 1 (蛋白名), MPIP1_HUMAN.
产品名称:

Human CDC25A/ M-phase inducer phosphatase 1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Dual specificity phosphatase Cdc25A

序列号:
P30304
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human CDC25A Protein
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Human CDC25A Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 3p21.31 by HGNC 3p21.31 by Entrez Gene 3p21.31 by Ensembl
CDC25A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CCNB1/cyclin B1. Interacts with YWHAE/14-3-3 epsilon when phosphorylated. Interacts with CUL1 specifically when CUL1 is neddylated and active. Interacts with BTRC/BTRCP1 and FBXW11/BTRCP2. Interactions with CUL1, BTRC and FBXW11 are enhanced upon DNA damage. Interacts with PIM1. Interacts with CHEK2; mediates CDC25A phosphorylation and degradation in response to infrared-induced DNA damages. Interacts with HSP90AB1; prevents heat shock-mediated CDC25A degradation and contributes to cell cycle progression (PubMed:22843495).


功能:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins."

[2].
"Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A."

[3].
"NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling."

[4].
"Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents."

[5].
"Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint."

[6].
"Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding."

[7].
"Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints."

[8].
"The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis."

[9].
"Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells."

[10].
"Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors."
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