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MPDZ (基因名), Multiple PDZ domain protein (蛋白名), MPDZ_HUMAN.
产品名称:

Human MPDZ/ Multiple PDZ domain protein Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Multi-PDZ domain protein 1, MUPP1

序列号:
O75970
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MPDZ Protein
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Human MPDZ Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 9p23 by HGNC 9p23 by Entrez Gene 9p23 by Ensembl
MPDZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with FAT4 (via cytoplasmic domain) (By similarity). Interacts with the adenovirus type 9 E4-ORF1 protein. Interacts with DLL1.


功能:
Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses.


亚细胞位置:
Cell membrane Peripheral membrane protein Cytoplasmic side Apical cell membrane Peripheral membrane protein Cytoplasmic side Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cell projection Dendrite Cell junction Tight junction Cell junction Synapse Cell junction Synapse Synaptosome Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR.


该产品尚未在任何出版物中被引用。

[1].
"SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation."

[2].
"Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure."

[3].
"Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo."

[4].
"Cloning and characterization of MUPP1, a novel PDZ domain protein."

[5].
"Mutation in MPDZ causes severe congenital hydrocephalus."
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