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MAP2K7 (基因名), Dual specificity mitogen-activated protein kinase kinase 7 (蛋白名), MP2K7_HUMAN.
产品名称:

Human MAP2K7/ Dual specificity mitogen-activated protein kinase kinase 7 Recombinant Protein
双特异性分裂素激活蛋白激酶7

货号:

R15099h

商标:
EIAab®
监管等级:
别名:

JNK-activating kinase 2, MAPK/ERK kinase 7, Stress-activated protein kinase kinase 4, c-Jun N-terminal kinase kinase 2, MEK 7, SAPK kinase 4, JNK kinase 2, MAP kinase kinase 7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

序列号:
O14733
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human MAP2K7 Protein
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Human MAP2K7 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.2 by HGNC 19p13.2 by Entrez Gene 19p13.2 by Ensembl
MAP2K7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.


功能:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.


亚细胞位置:
Nucleus Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38."

[2].
"Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1."

[3].
"The JIP group of mitogen-activated protein kinase scaffold proteins."

[4].
"Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli."

[5].
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase."

[6].
"ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion."

[7].
"Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation."

[8].
"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."

[9].
"Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases."

[10].
"The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway."
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