MAP2K7 (基因名), Dual specificity mitogen-activated protein kinase kinase 7 (蛋白名), MP2K7_HUMAN.
Human MAP2K7/ Dual specificity mitogen-activated protein kinase kinase 7 Recombinant Protein
JNK-activating kinase 2, MAPK/ERK kinase 7, Stress-activated protein kinase kinase 4, c-Jun N-terminal kinase kinase 2, MEK 7, SAPK kinase 4, JNK kinase 2, MAP kinase kinase 7, JNKK2, MEK7, MKK7, PRKMK7, SKK4
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1 (By similarity). Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
MAASSLEQKL | SRLEAKLKQE | NREARRRIDL | NLDISPQRPR | PTLQLPLAND |
GGSRSPSSES | SPQHPTPPAR | PRHMLGLPST | LFTPRSMESI | EIDQKLQEIM |
KQTGYLTIGG | QRYQAEINDL | ENLGEMGSGT | CGQVWKMRFR | KTGHVIAVKQ |
MRRSGNKEEN | KRILMDLDVV | LKSHDCPYIV | QCFGTFITNT | DVFIAMELMG |
TCAEKLKKRM | QGPIPERILG | KMTVAIVKAL | YYLKEKHGVI | HRDVKPSNIL |
LDERGQIKLC | DFGISGRLVD | SKAKTRSAGC | AAYMAPERID | PPDPTKPDYD |
IRADVWSLGI | SLVELATGQF | PYKNCKTDFE | VLTKVLQEEP | PLLPGHMGFS |
GDFQSFVKDC | LTKDHRKRPK | YNKLLEHSFI | KRYETLEVDV | ASWFKDVMAK |
TESPRTSGVL | SQPHLPFFR
"Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38."
"Cloning and expression of human mitogen-activated protein kinase kinase 7gamma1."
"The JIP group of mitogen-activated protein kinase scaffold proteins."
"Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli."
"Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase."
"ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion."
"Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation."
"Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein."
"Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases."
"The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway."
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