MAP2K6 (基因名), Dual specificity mitogen-activated protein kinase kinase 6 (蛋白名), MP2K6_HUMAN.
Human MAP2K6/ Dual specificity mitogen-activated protein kinase kinase 6 Recombinant Protein
MAPK/ERK kinase 6, Stress-activated protein kinase kinase 3, MEK 6, SAPK kinase 3, MAP kinase kinase 6, MEK6, MKK6, PRKMK6, SKK3
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Dimer. Interacts with Yersinia yopJ. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR.
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.
Nucleus Cytoplasm Cytoplasm Cytoskeleton Binds to microtubules.
MSQSKGKKRN | PGLKIPKEAF | EQPQTSSTPP | RDLDSKACIS | IGNQNFEVKA |
DDLEPIMELG | RGAYGVVEKM | RHVPSGQIMA | VKRIRATVNS | QEQKRLLMDL |
DISMRTVDCP | FTVTFYGALF | REGDVWICME | LMDTSLDKFY | KQVIDKGQTI |
PEDILGKIAV | SIVKALEHLH | SKLSVIHRDV | KPSNVLINAL | GQVKMCDFGI |
SGYLVDSVAK | TIDAGCKPYM | APERINPELN | QKGYSVKSDI | WSLGITMIEL |
AILRFPYDSW | GTPFQQLKQV | VEEPSPQLPA | DKFSAEFVDF | TSQCLKKNSK |
ERPTYPELMQ | HPFFTLHESK | GTDVASFVKL | ILGD
"Characterization of the structure and function of a novel MAP kinase kinase (MKK6)."
"Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation."
"Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase."
"Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation."
"The MKK6/p38 mitogen-activated protein kinase pathway is capable of inducing SOCS3 gene expression and inhibits IL-6-induced transcription."
"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."
"Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade."
"A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3."
"Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells."
"Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients."
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