MAP2K4 (基因名), Dual specificity mitogen-activated protein kinase kinase 4 (蛋白名), MP2K4_HUMAN.
Human MAP2K4/ Dual specificity mitogen-activated protein kinase kinase 4 Recombinant Protein
JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, Stress-activated protein kinase kinase 1, c-Jun N-terminal kinase kinase 1, MEK 4, SEK1, SAPK kinase 1, JNKK, MAP kinase kinase 4, JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1, SKK1
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Interacts with SPAG9 (By similarity). Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2, MAPK10/JNK3, MAPK11 and MAPK14. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with ARRB1, ARRB2 and MAPK8IP3/JIP3.
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
MAAPSPSGGG | GSGGGSGSGT | PGPVGSPAPG | HPAVSSMQGK | RKALKLNFAN |
PPFKSTARFT | LNPNPTGVQN | PHIERLRTHS | IESSGKLKIS | PEQHWDFTAE |
DLKDLGEIGR | GAYGSVNKMV | HKPSGQIMAV | KRIRSTVDEK | EQKQLLMDLD |
VVMRSSDCPY | IVQFYGALFR | EGDCWICMEL | MSTSFDKFYK | YVYSVLDDVI |
PEEILGKITL | ATVKALNHLK | ENLKIIHRDI | KPSNILLDRS | GNIKLCDFGI |
SGQLVDSIAK | TRDAGCRPYM | APERIDPSAS | RQGYDVRSDV | WSLGITLYEL |
ATGRFPYPKW | NSVFDQLTQV | VKGDPPQLSN | SEEREFSPSF | INFVNLCLTK |
DESKRPKYKE | LLKHPFILMY | EERAVEVACY | VCKILDQMPA | TPSSPMYVD
"The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population."
"A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates."
"Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene."
"Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2."
"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."
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