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MAP2K3 (基因名), Dual specificity mitogen-activated protein kinase kinase 3 (蛋白名), MP2K3_HUMAN.
产品名称:

Human MAP2K3/ Dual specificity mitogen-activated protein kinase kinase 3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MAPK/ERK kinase 3, Stress-activated protein kinase kinase 2, MEK 3, SAPK kinase 2, MAP kinase kinase 3, MEK3, MKK3, PRKMK3, SKK2

序列号:
P46734
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MAP2K3 Protein
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Human MAP2K3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 17p11.2 by HGNC 17p11.2 by Entrez Gene 17p11.2 by Ensembl
MAP2K3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of a signaling complex containing at least AKAP13, PKN1, MAPK14, ZAK and MAP2K3. Within this complex, AKAP13 interacts directly with PKN1, which in turn recruits MAPK14, MAP2K3 and ZAK (PubMed:21224381). Binds to DYRK1B/MIRK and increases its kinase activity (PubMed:11980910). Part of a complex with MAP3K3, RAC1 and CCM2 (By similarity). Interacts with ARRB1 (PubMed:16709866). Interacts with Yersinia yopJ (PubMed:16728640).


功能:
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway."

[2].
"Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms."

[3].
"Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients."

[4].
"MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2."

[5].
"DJ-1 modulates the p38 mitogen-activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1."

[6].
"MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival."

[7].
"Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3."

[8].
"Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation."

[9].
"Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation."

[10].
"MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation."
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