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MAP2K2 (基因名), Dual specificity mitogen-activated protein kinase kinase 2 (蛋白名), MP2K2_HUMAN.
产品名称:

Human MAP2K2/ Dual specificity mitogen-activated protein kinase kinase 2 Recombinant Protein
双特异性丝裂原活化蛋白激酶2

货号:

R10344h

商标:
EIAab®
监管等级:
别名:

ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MAP kinase kinase 2, MEK2, MKK2, PRKMK2

序列号:
P36507
来源:
E.coli
种属:
Human
标签:
His
序列:
Recombinant protein
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Neurosciences
Human MAP2K2 Protein
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Human MAP2K2 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 19p13.3 by HGNC 19p13.3 by Entrez Gene 19p13.3 by Ensembl
MAP2K2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742).


功能:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.


亚细胞位置:
Cytoplasm Membrane Peripheral membrane protein Membrane localization is probably regulated by its interaction with KSR1.


该产品尚未在任何出版物中被引用。

[1].
"Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2."

[2].
"Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis."

[3].
"Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations."

[4].
"Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations."

[5].
"Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum."

[6].
"Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome."

[7].
"Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization."

[8].
"RNAi-mediated MEK1 knock-down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo."

[9].
"Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2."

[10].
"Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
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