首页 > 重组蛋白 > Human SLC16A1 Recombinant Protein

SLC16A1 (基因名), Monocarboxylate transporter 1 (蛋白名), MOT1_HUMAN.

产品名称:

Human SLC16A1/ Monocarboxylate transporter 1 Recombinant Protein
单羧基运输蛋白1

货号:

R7726h

商标:

EIAab^®

监管等级:

RUO

别名:

Solute carrier family 16 member 1, MCT 1, MCT1

序列号:

P53985

来源:

E.coli

种属:

Human

标签:

His

纯度:

>90% by SDS-PAGE

浓度:

Reconstitution Dependent

形态:

Liquid

内毒素水平:

Please contact protein@eiaab.com The technician for more information.

应用:

存储缓冲液:

50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)

存储:

Store at -20°C. (Avoid repeated freezing and thawing.)

研究领域:

规格 & 价格:

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Human SLC16A1 Protein

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产品说明书

说明书:

MSDS:

在线询价

数据
文献
出版物
序列 / 3D
常见问题解答
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R&D 技术数据

更多信息，请参阅手册，或联系我们的技术支持: tech@eiaab.com.

基因位点

Cytogenetic band: 1p13.2 by HGNC 1p13.2 by Entrez Gene 1p13.2 by Ensembl

SLC16A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

通用注释

亚单元:

Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.

功能:

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

亚细胞位置:

Cell membrane Multi-pass membrane protein

数据库链接

UniGene:

Hs.75231

STRING:

9606.ENSP00000358640

KEGG:

hsa:6566

MIM:

245340

Pfam:

PF07690

Uniprot:

P53985

相关产品

Mouse Slc16a1 ELISA Kit

Rat Slc16a1 ELISA Kit

Bovine SLC16A1 ELISA Kit

Mouse Slc16a1 CLIA Kit

Rat Slc16a1 CLIA Kit

序列长度:

500

序列:

仅供参考，详细请咨询（services@eiaab.com）

50:

100:

150:

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500:

3D 模型:

3D 结构:

免疫原序列:

验证序列:

该产品尚未在任何出版物中被引用。

[1].

"cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12."

(PMID: 7835905)

[2].

"Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore."

(PMID: 19881260)

[3].

"Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells."

(PMID: 17701893)

[4].

"Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."

(PMID: 15505343)

[5].

"The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis."

(PMID: 11944921)

[6].

"Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport."

(PMID: 10590411)

[7].

"Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle."

(PMID: 8124722)

[8].

"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."

(PMID: 24390345)

[9].

"Monocarboxylate transporter 1 deficiency and ketone utilization."

(PMID: 25390740)

[10].

"Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes."

(PMID: 19876643)

[1].

人单羧基运输蛋白1(SLC16A1)重组蛋白是否是无菌的？

蛋白试剂瓶和蛋白保存液是经过高压灭菌的，但也不能保证蛋白是完全无菌的。如果要求蛋白是无菌的，可以用0.2微米的滤器对蛋白进行过滤。

[2].

人单羧基运输蛋白1(SLC16A1)重组蛋白的保存缓冲液是什么？

纯化后的蛋白保存在PBS（58mM Na2HPO4, 17mM NaH2PO4, 68mM NaCl, pH7.4）里，并往里面加入500mM咪唑和10%甘油。

[3].

怎样确定人单羧基运输蛋白1(SLC16A1)重组蛋白的浓度？

蛋白浓度的确定没有一个统一的标准，这主要取决于蛋白的氨基酸序列。伊艾博是根据不同测试的组合来测定蛋白浓度。考马斯亮蓝法、BCA法、氨基酸序列和氨基酸全序列分析法等都用来测定蛋白浓度。

[4].

人单羧基运输蛋白1(SLC16A1)重组蛋白蛋白保存条件是怎样的？

蛋白应保存在 -20℃或 -80℃条件下，为了避免反复冻融，可以将蛋白分装成小份保存。

[5].

人单羧基运输蛋白1(SLC16A1)重组蛋白是否可以用于活体实验？

重组蛋白没有用于任何的活体实验，因此蛋白的活性和半衰期是不确定的。

[6].

人单羧基运输蛋白1(SLC16A1)重组蛋白的保质期是多久？

在适当的保存条件下，从购买之日起蛋白可以稳定保存6-12个月。适当的保存条件是:蛋白保存在-20°C o或 -80℃，保证蛋白的保存浓度高于0.1mg/ml，限制蛋白反复冻融的次数。我们公司常规的质量检测保证所有产品在销售时都有可接受的生物活性。但是我们不能控制终端用户蛋白的保存条件。如果产品在有效期内出现问题，请联系我们的技术支持。

[7].

你们蛋白和抗体的报价是怎么样的？

我们将根据你需要的蛋白和抗体的大小进行报价。

[8].

人单羧基运输蛋白1(SLC16A1)重组蛋白是否能够提供蛋白片段？

我们现有的人的蛋白的序列可以有很多。你可以选择你感兴趣的靶向部分，我们将会按您的需求提供蛋白和抗体。

[9].

人单羧基运输蛋白1(SLC16A1)重组蛋白的货期或发货时间一般是多长？

具体指标的货期需要确定。最快一周，最长可能一个月。

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