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首页  >  重组蛋白  >  Human SLC16A1 Recombinant Protein
SLC16A1 (基因名), Monocarboxylate transporter 1 (蛋白名), MOT1_HUMAN.
产品名称:

Human SLC16A1/ Monocarboxylate transporter 1 Recombinant Protein
单羧基运输蛋白1

货号:

R7726h

商标:
EIAab®
监管等级:
别名:

Solute carrier family 16 member 1, MCT 1, MCT1

序列号:
P53985
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human SLC16A1 Protein
规格 & 价格: cart
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Human SLC16A1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


R&D 技术数据
更多信息,请参阅手册,或联系我们的技术支持: tech@eiaab.com.
基因位点
Cytogenetic band: 1p13.2 by HGNC 1p13.2 by Entrez Gene 1p13.2 by Ensembl
SLC16A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with EMB. Interaction with either BSG or EMB is required for expression at the cell membrane (By similarity). Interacts with BSG; this is required for expression at the cell membrane.


功能:
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.


亚细胞位置:
Cell membrane Multi-pass membrane protein


该产品尚未在任何出版物中被引用。

[1].
"cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12."

[2].
"Genetic variations in the MCT1 (SLC16A1) gene in the Chinese population of Singapore."

[3].
"Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells."

[4].
"Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes."

[5].
"The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis."

[6].
"Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport."

[7].
"Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle."

[8].
"Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico."

[9].
"Monocarboxylate transporter 1 deficiency and ketone utilization."

[10].
"Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes."
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