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MORC3 (基因名), MORC family CW-type zinc finger protein 3 (蛋白名), MORC3_HUMAN.
产品名称:

Human MORC3/ MORC family CW-type zinc finger protein 3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Nuclear matrix protein 2, Zinc finger CW-type coiled-coil domain protein 3, KIAA0136, NXP2, ZCWCC3

序列号:
Q14149
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Human MORC3 Protein
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Human MORC3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 21q22.12 by HGNC 21q22.12 by Entrez Gene 21q22.12 by Ensembl
MORC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Homodimer (PubMed:17332504). The sumoylated form interacts with PML (via SUMO-interacting motif) (PubMed:20501696, PubMed:17332504). Interacts with PT53 (PubMed:17332504). Interacts with influenza A virus PA and PB1 polymerase subunits during infection (PubMed:26202233).


功能:
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).


亚细胞位置:
Nucleus Nucleoplasm Nucleus matrix Nucleus PML body Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent.


该产品尚未在任何出版物中被引用。

[1].
"The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication."

[2].
"Two-step colocalization of MORC3 with PML nuclear bodies."

[3].
"Dynamic regulation of p53 subnuclear localization and senescence by MORC3."

[4].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."

[5].
"The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants."

[6].
"The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains."

[7].
"The DNA sequence of human chromosome 21."

[8].
"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."

[9].
"An Interaction Landscape of Ubiquitin Signaling."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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