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首页  >  重组蛋白  >  Mouse Morc2a Recombinant Protein
Morc2a (基因名), ATPase MORC2A (蛋白名), MOR2A_MOUSE.
产品名称:

Mouse Morc2a/ ATPase MORC2A Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MORC family CW-type zinc finger protein 2A, Zinc finger CW-type coiled-coil domain protein 1, Kiaa0852, Zcwcc1

序列号:
Q69ZX6
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Mouse Morc2a Protein
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Mouse Morc2a Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Homodimerizes upon ATP-binding and dissociate upon ATP hydrolysis; homodimerization is required for gene silencing (By similarity). Binds histone H3 independently of the methylation status at 'Lys-9' (PubMed:29728365). Interacts with HDAC4. Interacts with FAM208A/TASOR and MPHOSPH8; the interactions associate MORC2 with the HUSH complex which recruits MORC2 to heterochromatic loci (By similarity). Interacts with Morc2b (PubMed:29329290).


功能:
Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity).


亚细胞位置:
Nucleus Cytoplasm Cytosol Chromosome Nucleus matrix Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin.


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