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KIAA0753 (基因名), Protein moonraker (蛋白名), MOONR_HUMAN.
产品名称:

Human KIAA0753/ Protein moonraker Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

OFD1- and FOPNL-interacting protein, MNR, MNR, OFIP

序列号:
Q2KHM9
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human KIAA0753 Protein
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Human KIAA0753 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 17p13.1 by HGNC 17p13.1 by Entrez Gene 17p13.1 by Ensembl
KIAA0753 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with CEP63 (PubMed:24613305). Interacts with WDR62 (PubMed:26297806). Forms a complex with OFD1 and FOPNL/FOR20 (PubMed:26643951). Interacts with PCM1 (PubMed:26297806, PubMed:26643951).


功能:
Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:24613305, PubMed:26297806).


亚细胞位置:
Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriolar satellite Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Localization to centrioles and pericentriolar satellites may be mediated by interaction with PCM1.


该产品尚未在任何出版物中被引用。

[1].
"OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome."

[2].
"Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication."

[3].
"Proximity interactions among centrosome components identify regulators of centriole duplication."

[4].
"Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency."

[5].
"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."

[6].
"Molecular genetic findings and clinical correlations in 100 patients with Joubert syndrome and related disorders prospectively evaluated at a single center."

[7].
"Fifteen years of research on oral-facial-digital syndromes: from 1 to 16 causal genes."

[8].
"Architecture of the human interactome defines protein communities and disease networks."

[9].
"Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing."

[10].
"Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators."
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