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MOCS3 (基因名), Adenylyltransferase and sulfurtransferase MOCS3 (蛋白名), MOCS3_HUMAN.
产品名称:

Human MOCS3/ Adenylyltransferase and sulfurtransferase MOCS3 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Molybdenum cofactor synthesis protein 3, Molybdopterin synthase sulfurylase, MPT synthase sulfurylase, UBA4

序列号:
O95396
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MOCS3 Protein
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Human MOCS3 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 20q13.13 by HGNC 20q13.13 by Entrez Gene 20q13.13 by Ensembl
MOCS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Interacts with NFS1.


功能:
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs."

[2].
"Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry."

[3].
"Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans."

[4].
"The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteins."

[5].
"A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis."

[6].
"A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway."

[7].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[8].
"Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH."

[9].
"The DNA sequence and comparative analysis of human chromosome 20."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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