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Mob1b (基因名), MOB kinase activator 1B (蛋白名), MOB1B_MOUSE.
产品名称:

Mouse Mob1b/ MOB kinase activator 1B Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Mob1 homolog 1A, Mps one binder kinase activator-like 1A, Mobkl1a

序列号:
Q8BPB0
来源:
E.coli
种属:
Mouse
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
Cancer
Mouse Mob1b Protein
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Mouse Mob1b Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


通用注释


亚单元:
Binds STK38L. Interacts with LATS1 and LATS2.


功能:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.


亚细胞位置:
Cytoplasm Nucleus


该产品尚未在任何出版物中被引用。
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