MORF4L2 (基因名), Mortality factor 4-like protein 2 (蛋白名), MO4L2_HUMAN.
Human MORF4L2/ Mortality factor 4-like protein 2 Recombinant Protein
MORF-related gene X protein, Protein MSL3-2, Transcription factor-like protein MRGX, KIAA0026, MRGX
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors.
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
MSSRKQGSQP | RGQQSAEEEN | FKKPTRSNMQ | RSKMRGASSG | KKTAGPQQKN |
LEPALPGRWG | GRSAENPPSG | SVRKTRKNKQ | KTPGNGDGGS | TSEAPQPPRK |
KRARADPTVE | SEEAFKNRME | VKVKIPEELK | PWLVEDWDLV | TRQKQLFQLP |
AKKNVDAILE | EYANCKKSQG | NVDNKEYAVN | EVVAGIKEYF | NVMLGTQLLY |
KFERPQYAEI | LLAHPDAPMS | QVYGAPHLLR | LFVRIGAMLA | YTPLDEKSLA |
LLLGYLHDFL | KYLAKNSASL | FTASDYKVAS | AEYHRKAL
"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."
"MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner."
"Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split."
"Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes."
"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
"The DNA sequence of the human X chromosome."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Architecture of the human interactome defines protein communities and disease networks."
"Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis."
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