MORF4L1 (基因名), Mortality factor 4-like protein 1 (蛋白名), MO4L1_HUMAN.
Human MORF4L1/ Mortality factor 4-like protein 1 Recombinant Protein
MORF-related gene 15 protein, Protein MSL3-1, Transcription factor-like protein MRG15, FWP006, HSPC008, HSPC061, PP368, MRG15
>90% by SDS-PAGE
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50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
Store at -20°C. (Avoid repeated freezing and thawing.)
Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the mSin3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with RB1 and KAT8. May also interact with PHF12 and one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors. Interacts with the N-terminus of MRFAP1. Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts with the entire BRCA complex, which contains BRCA1, PALB2, BRCA2 and RAD51. Interacts with PALB2. Forms a complex with MSL1 and NUPR1.
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci.
MAPKQDPKPK | FQEGERVLCF | HGPLLYEAKC | VKVAIKDKQV | KYFIHYSGWN |
KKSAVRPRRS | EKSLKTHEDI | VALFPVPEGA | PSVHHPLLTS | SWDEWVPESR |
VLKYVDTNLQ | KQRELQKANQ | EQYAEGKMRG | AAPGKKTSGL | QQKNVEVKTK |
KNKQKTPGNG | DGGSTSETPQ | PPRKKRARVD | PTVENEETFM | NRVEVKVKIP |
EELKPWLVDD | WDLITRQKQL | FYLPAKKNVD | SILEDYANYK | KSRGNTDNKE |
YAVNEVVAGI | KEYFNVMLGT | QLLYKFERPQ | YAEILADHPD | APMSQVYGAP |
HLLRLFVRIG | AMLAYTPLDE | KSLALLLNYL | HDFLKYLAKN | SATLFSASDY |
EVAPPEYHRK | AV
"MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks."
"Multipurpose MRG domain involved in cell senescence and proliferation exhibits structural homology to a DNA-interacting domain."
"The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14."
"Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."
"Role for the mortality factors MORF4, MRGX, and MRG15 in transcriptional repression via associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split."
"MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."
"MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"MRG15 is a novel PALB2-interacting factor involved in homologous recombination."
"p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage."
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