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MN1 (基因名), Transcriptional activator MN1 (蛋白名), MN1_HUMAN.
产品名称:

Human MN1/ Transcriptional activator MN1 Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

Probable tumor suppressor protein MN1

序列号:
Q10571
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MN1 Protein
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Human MN1 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 22q12.1 by HGNC 22q12.1 by Entrez Gene 22q12.1 by Ensembl
MN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
N/A


功能:
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。

[1].
"Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma."

[2].
"Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11."

[3].
"Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling."

[4].
"MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression."

[5].
"The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence."

[6].
"The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription."

[7].
"MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML."

[8].
"Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases."

[9].
"MN1 and PTEN gene expression in acute myeloid leukemia."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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