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MMS19 (基因名), MMS19 nucleotide excision repair protein homolog (蛋白名), MMS19_HUMAN.
产品名称:

Human MMS19/ MMS19 nucleotide excision repair protein homolog Recombinant Protein

货号:
-
商标:
EIAab®
监管等级:
别名:

MET18 homolog, MMS19-like protein, hMMS19, MMS19L

序列号:
Q96T76
来源:
E.coli
种属:
Human
标签:
His
纯度:
>90% by SDS-PAGE
浓度:
Reconstitution Dependent
形态:
Liquid
内毒素水平:
Please contact protein@eiaab.com The technician for more information.
应用:
存储缓冲液:
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10%glycerol(PH8.0)
存储:
Store at -20°C. (Avoid repeated freezing and thawing.)
研究领域:
-
Human MMS19 Protein
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Human MMS19 Protein
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产品说明书
说明书: 下载说明书
MSDS: MSDS


基因位点
Cytogenetic band: 10q24.1 by HGNC 10q24.1 by Entrez Gene 10q24.1 by Ensembl
MMS19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
基因位点
通用注释


亚单元:
Component of the CIA complex. Component of the MMXD complex, composed of CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex.


功能:
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Spindle


该产品尚未在任何出版物中被引用。

[1].
"Cloning of a human homolog of the yeast nucleotide excision repair gene MMS19 and interaction with transcription repair factor TFIIH via the XPB and XPD helicases."

[2].
"MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity."

[3].
"MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism."

[4].
"Cytosolic Iron-Sulfur Assembly Is Evolutionarily Tuned by a Cancer-Amplified Ubiquitin Ligase."

[5].
"IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway."

[6].
"MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation."

[7].
"Variation within DNA repair pathway genes and risk of multiple sclerosis."

[8].
"Nucleotide excision repair pathway polymorphisms and pancreatic cancer risk: evidence for role of MMS19L."

[9].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."

[10].
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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